Understanding how certain cells develop in the spinal cord
Assessing the mechanisms directing cell fate in the dorsal spinal cord
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11067765
This study is looking at how certain cells in the spinal cord that help us feel touch and pain develop, with the hope of finding ways to create these cells from stem cells, which could lead to better treatments for injuries and new ways to test medications.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11067765 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that guide the development of dorsal interneurons in the spinal cord, which are crucial for processing sensory information like touch and pain. By studying these cells in various models, including mouse and chicken, the researchers aim to uncover how specific signaling pathways, particularly those involving bone morphogenetic proteins (BMPs), influence cell fate. The ultimate goal is to develop methods to generate these cells from pluripotent stem cells, potentially leading to new treatments for sensory circuit damage and drug testing platforms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting sensory processing or spinal cord injuries.
Not a fit: Patients with conditions unrelated to sensory processing or spinal cord function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies for repairing damaged sensory pathways in patients.
How similar studies have performed: Previous research has shown promise in using similar approaches to manipulate cell fate and repair sensory circuits, indicating potential for success.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BUTLER, SAMANTHA J — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: BUTLER, SAMANTHA J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.