Understanding how certain cells develop during pregnancy
Regulation of Invasive Trophoblast Cell Lineage Development
['FUNDING_OTHER'] · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · NIH-10932408
This study is looking at a protein called ASCL2 to see how it helps develop important cells that support a healthy pregnancy, which could help us understand issues like preeclampsia or growth problems in babies, ultimately aiming to find better treatments for these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S MERCY HOSP (KANSAS CITY, MO) (nih funded) |
| Locations | 1 site (KANSAS CITY, UNITED STATES) |
| Trial ID | NIH-10932408 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific protein, ASCL2, in the development of invasive trophoblast cells, which are crucial for proper blood supply to the fetus during pregnancy. By using advanced techniques like ATAC sequencing and creating mutant animal models, the researchers aim to uncover how ASCL2 influences the formation of these cells and their impact on placental health. This study could provide insights into why some pregnancies face complications such as preeclampsia or growth restrictions. Patients may benefit from a better understanding of these conditions and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals or those planning to become pregnant, particularly those with a history of pregnancy complications.
Not a fit: Patients who are not pregnant or do not plan to become pregnant may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved outcomes for pregnancies at risk of complications related to placental development.
How similar studies have performed: Similar research has shown promise in understanding placental development and its implications for pregnancy health, indicating that this approach could yield valuable insights.
Where this research is happening
KANSAS CITY, UNITED STATES
- CHILDREN'S MERCY HOSP (KANSAS CITY, MO) — KANSAS CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VARBERG, KAELA MARGARET — CHILDREN'S MERCY HOSP (KANSAS CITY, MO)
- Study coordinator: VARBERG, KAELA MARGARET
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.