Understanding how certain cells contribute to the growth of lesions in pulmonary hypertension
Defining the cellular and molecular mechanisms driving neointimal lesion growth in pulmonary hypertension
This study is looking into how certain cells in the lungs grow in a way that makes pulmonary hypertension worse, with the hope of finding better treatments to help people with this condition feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11017000 on NIH RePORTER |
What this research studies
This research investigates the cellular and molecular mechanisms that lead to the growth of neointimal lesions in pulmonary hypertension, a serious condition affecting the pulmonary arteries. The team aims to identify specific cells responsible for lesion expansion and understand the signals from surrounding endothelial cells that regulate this growth. By utilizing advanced techniques such as genetic lineage tracing and bioinformatics analysis, the researchers hope to uncover the biological pathways involved in this process. The ultimate goal is to develop more effective therapies that can target these mechanisms and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with pulmonary hypertension, particularly those experiencing significant disease progression.
Not a fit: Patients with pulmonary hypertension who are not experiencing neointimal lesion growth or those with other unrelated pulmonary conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the growth of harmful lesions in pulmonary hypertension, potentially improving survival rates and quality of life for patients.
How similar studies have performed: Previous research has shown promise in understanding cellular mechanisms in other vascular diseases, suggesting that this approach may yield valuable insights into pulmonary hypertension as well.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Kumar, Maya Elise — Stanford University
- Study coordinator: Kumar, Maya Elise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.