Understanding how certain cells contribute to Sjögren’s disease
Official title: Defining Sjögren’s pathogenesis by endotype: maladaptive responses of endogenous salivary gland mesenchymal stromal cells
Funded at University of Wisconsin-Madison · NIH-11164797 · Data updated 2026-11-12
This study is looking at how different types of Sjögren's disease affect people in unique ways by examining certain cells in the salivary glands, and it hopes to find new treatments that are better suited for each type, so patients may be asked to share samples and information to help with this important research.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | August 9, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $686,512 |
| NIH project number | 5R01DE033396-02 |
| Project ID | NIH-11164797 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Sjögren's disease, particularly those experiencing severe symptoms of dryness and multi-organ involvement.
✕Less likely to help
Patients with Sjögren's disease who do not exhibit significant symptoms or those with other unrelated conditions may not benefit from this research.
What this research studies
This research investigates Sjögren's disease, an autoimmune condition that causes severe dryness in the mouth and eyes, by identifying specific patient subgroups, known as endotypes, based on their biological responses. The study focuses on mesenchymal stromal cells (MSCs) found in the salivary glands, which may play a key role in the disease's progression. By comparing these cells in patients with different endotypes, the research aims to uncover how they respond to unique cytokines and potentially lead to new targeted therapies. Patients may be involved in providing samples and data to help define these endotypes and their implications for treatment.
Why it matters
Potential benefit: If successful, this research could lead to new, targeted therapies for Sjögren's disease, improving the quality of life for patients.
How similar studies have gone: Previous research has shown promise in understanding autoimmune diseases through the study of specific cell types, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Mccoy, Sara — University of Wisconsin-Madison
- Study coordinator: Mccoy, Sara
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.