Understanding how certain cells contribute to lung transplant failure
Official title: Translational Dysregulation Driving Mesenchymal Cell Fibrogenic Transformation and Chronic Lung Allograft Dysfunction
Funded at Emory University · NIH-10864502 · Data updated 2026-11-12
This study is looking into how certain cells in the lungs might contribute to problems like airway blockage in people who have had lung transplants, with the hope of finding new ways to help these patients breathe better and keep their new lungs healthy for longer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | December 8, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $574,636 |
| NIH project number | 7R01HL094622-14 |
| Project ID | NIH-10864502 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are lung transplant recipients who are experiencing or are at risk for chronic lung allograft dysfunction.
✕Less likely to help
Patients who have not undergone lung transplantation or those with other unrelated lung conditions may not benefit from this research.
What this research studies
This research investigates the mechanisms behind chronic lung allograft dysfunction (CLAD), a condition affecting many lung transplant recipients. It focuses on the role of mesenchymal cells in the development of bronchiolitis obliterans syndrome (BOS), a serious complication characterized by airway obstruction. The study aims to explore specific signaling pathways that lead to fibrotic changes in these cells, which may help identify new therapeutic strategies to prevent graft failure. By analyzing the molecular interactions involved, the research seeks to provide insights that could improve long-term outcomes for lung transplant patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve the longevity and function of lung transplants.
How similar studies have gone: Previous research has shown promising results in understanding fibrotic processes in other transplant settings, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Lama, Vibha N — Emory University
- Study coordinator: Lama, Vibha N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.