Understanding how certain cells contribute to blood vessel changes in children with pulmonary hypertension
Exploiting neointimal and vascular smooth muscle cell heterogeneity to reveal mechanisms driving venous neointimal growth and vascular remodeling in pediatric pulmonary hypertension
This study is looking at how certain changes in blood vessel cells might cause blockages in the veins of children with pulmonary hypertension, with the hope that understanding these changes will help create better treatments for them.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11084367 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the growth of obstructive lesions in the veins of children suffering from pediatric pulmonary hypertension (PPH). It focuses on the differences in vascular smooth muscle cells and how these variations may influence the development of neointimal lesions. By utilizing advanced imaging techniques and biocomputational analysis, the study aims to uncover the molecular controls that drive these changes. This knowledge could lead to better-targeted therapies for managing PPH.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years diagnosed with pediatric pulmonary hypertension.
Not a fit: Patients with pulmonary hypertension due to causes unrelated to venous remodeling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the growth of harmful lesions in the veins of children with pulmonary hypertension.
How similar studies have performed: While research on arterial disease is more common, this study explores a relatively novel area concerning venous changes in pulmonary hypertension, indicating a unique approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Steffes, Lea — Stanford University
- Study coordinator: Steffes, Lea
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.