Understanding how certain cells contribute to alcohol-related liver disease using humanized mice
Official title: Non-parenchymalcells drive the key features of alcohol associated hepatitis (AAH) in a fully humanized mouse liver
Funded at Yale University · NIH-11058931 · Data updated 2026-11-12
This study is looking at how certain immune cells in the liver react to alcohol-related liver disease, using special mice that act like human livers, to help find better ways to treat people with this serious condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | June 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $688,199 |
| NIH project number | 1R01AA031489-01A1 |
| Project ID | NIH-11058931 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults suffering from alcohol-associated hepatitis or related liver conditions.
✕Less likely to help
Patients with liver diseases not related to alcohol consumption may not benefit from this research.
What this research studies
This research investigates the role of non-parenchymal cells in alcohol-associated hepatitis, a severe liver condition caused by excessive alcohol consumption. By utilizing a specially designed humanized mouse model that mimics human liver conditions, the researchers aim to explore the complex interactions between liver cells and the immune system. The study involves feeding these mice alcohol to replicate the disease features seen in humans, which could lead to better understanding and treatment options for patients suffering from alcohol-related liver disease.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with alcohol-related liver disease.
How similar studies have gone: Previous research has shown promise in using humanized mouse models to study liver diseases, indicating potential for success in this approach.
Where this research is happening
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Yale University
New Haven, United States Active
Researchers
- Principal investigator: Flavell, Richard a — Yale University
- Study coordinator: Flavell, Richard a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.