Understanding how certain cells change in basal-like breast cancer
A premalignant chronology of cell-state variability in basal-like breast cancer
This study is looking at how certain changes in cells can lead to a type of breast cancer that affects many African American women, using a special mouse model to better understand the early signs of this disease and how it interacts with the immune system.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11004984 on NIH RePORTER |
What this research studies
This research investigates the early changes in cell states that lead to basal-like breast cancer, particularly in African American women. By using a unique mouse model, researchers aim to visualize and analyze the progression of premalignant lesions in the mammary gland. The study focuses on the genetic factors involved, specifically the loss of tumor suppressor genes BRCA1 and TP53, and how these changes affect immune responses in the body. The goal is to uncover the cellular and molecular transitions that contribute to the development of this aggressive cancer subtype.
Who could benefit from this research
Good fit: Ideal candidates for this research include African American women who are at risk for or have a family history of breast cancer.
Not a fit: Patients with other subtypes of breast cancer or those without a genetic predisposition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potentially new strategies for preventing or treating basal-like breast cancer.
How similar studies have performed: While the approach of using genetically engineered models is established, the specific focus on basal-like breast cancer and the methods employed in this research are relatively novel.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Janes, Kevin a — University of Virginia
- Study coordinator: Janes, Kevin a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.