Understanding how certain cells are removed from developing embryos in mice
Biological mechanisms that eliminate aneuploid cells from a mosaic conceptus in the mouse model system
This study is looking at how cells with the wrong number of chromosomes can impact the early development of mouse embryos, and it aims to find ways to safely get rid of these cells to help improve pregnancy outcomes for people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project ID | NIH-11010850 on NIH RePORTER |
What this research studies
This research investigates how aneuploid cells, which have an abnormal number of chromosomes, affect the development of embryos in mice. By using a mouse model, the researchers will explore the processes that occur during the early stages of embryo development, particularly focusing on how these abnormal cells can be eliminated without disrupting the overall development of the embryo. The study aims to uncover the biological mechanisms that allow for the successful removal of these cells, which could provide insights into improving pregnancy outcomes in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are women experiencing infertility issues, particularly those with a history of miscarriages linked to chromosomal abnormalities.
Not a fit: Patients who do not have issues related to chromosomal abnormalities or infertility may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for infertility related to chromosomal abnormalities.
How similar studies have performed: Previous research has shown promising results in understanding the effects of aneuploidy in various organisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Pasadena, United States
- California Institute of Technology — Pasadena, United States (Active)
Researchers
- Principal investigator: Zernicka-Goetz, Magdalena — California Institute of Technology
- Study coordinator: Zernicka-Goetz, Magdalena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.