Understanding how certain cells and tissue structures contribute to muscle fibrosis
Interdependency of fibroadipogenic progenitors and extracellular matrix that drive skeletal muscle fibrosis
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-11057712
This study is looking at how certain cells and the surrounding tissue affect muscle healing and stiffness, with the goal of finding new ways to help people with muscle diseases feel better and move more easily.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-11057712 on ClinicalTrials.gov |
What this research studies
This research investigates the role of fibro-adipogenic progenitors and the extracellular matrix in the development of skeletal muscle fibrosis, which can severely impair muscle function. The study aims to uncover how these progenitor cells interact with their mechanical environment and how this affects muscle regeneration and the effectiveness of potential therapies. By exploring these cellular interactions, the research seeks to identify new targets for antifibrotic treatments that could improve muscle health and mobility for patients with muscle diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with muscle diseases characterized by fibrosis, such as Duchenne muscular dystrophy.
Not a fit: Patients with muscle conditions that do not involve fibrosis or those who are not affected by muscle degeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve muscle function and mobility for patients suffering from muscle fibrosis.
How similar studies have performed: Previous research has shown promising results in understanding the role of cellular interactions in muscle regeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SMITH, LUCAS R — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: SMITH, LUCAS R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.