Understanding how certain cells affect uterine healing after childbirth
Official title: THE ROLE OF MESENCHYMAL PROGENITOR CELLS IN ABNORMAL UTERINE REPAIR
Funded at Yale University · NIH-11083618 · Data updated 2026-11-12
This study is looking at how certain cells in the uterus behave after childbirth and why some women develop problems like scar tissue that can affect their ability to get pregnant, especially after a procedure called D&C; the goal is to find ways to prevent these issues and help women heal better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | May 15, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $576,294 |
| NIH project number | 5R01HD109326-03 |
| Project ID | NIH-11083618 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who have recently undergone D&C and are experiencing issues related to intrauterine adhesions or infertility.
✕Less likely to help
Patients who have not undergone D&C or are not experiencing complications related to uterine healing may not benefit from this research.
What this research studies
This research investigates the role of endometrial mesenchymal stem/progenitor cells (eMPCs) in the abnormal healing of the uterus following childbirth. It focuses on why women who undergo dilation and curettage (D&C) postpartum are more likely to develop intrauterine adhesions, a condition that can lead to infertility and other complications. By using a novel mouse model that mimics human postpartum uterine injury, the study aims to uncover the differences in eMPCs' behavior and response to injury in postpartum versus nonpregnant conditions. The findings could provide insights into preventing and treating this debilitating condition.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for women suffering from infertility and complications related to abnormal uterine repair.
How similar studies have gone: Other research has shown promising results in understanding the role of stem cells in tissue repair, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Tal, Reshef — Yale University
- Study coordinator: Tal, Reshef
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.