Understanding how certain cells affect lung blood vessel changes
Role of CXCR2-mediated cell trafficking in pulmonary vascular remodeling
This study is looking at how a certain receptor in the body helps bring immune cells to the lungs, which might affect blood vessels and cause high blood pressure in the lungs, and it's for people with idiopathic pulmonary fibrosis and pulmonary hypertension to find new ways to help them feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10692849 on NIH RePORTER |
What this research studies
This research investigates the role of a specific receptor, CXCR2, in the recruitment of immune cells to the lungs, which may lead to changes in the blood vessels and pulmonary hypertension. By studying how these cells interact and contribute to lung conditions, the researchers aim to identify potential therapeutic targets for treatment. The approach involves analyzing blood samples from patients with idiopathic pulmonary fibrosis and pulmonary hypertension to understand the mechanisms at play. This knowledge could pave the way for new immunotherapies that could improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with idiopathic pulmonary fibrosis who also have pulmonary hypertension.
Not a fit: Patients with pulmonary conditions unrelated to pulmonary hypertension or idiopathic pulmonary fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for pulmonary hypertension and related lung diseases.
How similar studies have performed: Other research has shown promising results in understanding immune cell roles in lung diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Bryant, Andrew Justin — University of Florida
- Study coordinator: Bryant, Andrew Justin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.