Understanding how certain cells affect blood vessel changes in pulmonary hypertension
Official title: Mural cells contribution to vascular remodeling in flow induced pulmonary hypertension
Funded at Boston Children's Hospital · NIH-10985482 · Data updated 2026-11-12
This study is looking at how certain cells in blood vessels change when someone has pulmonary arterial hypertension (PAH), especially if it’s linked to heart problems from birth, and it aims to create a new animal model to help us understand the disease better and find new treatments that could help improve patients' health.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $167,940 |
| NIH project number | 1K08HL171843-01A1 |
| Project ID | NIH-10985482 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with congenital heart disease who are at risk for developing pulmonary arterial hypertension.
✕Less likely to help
Patients with pulmonary arterial hypertension not related to congenital heart disease may not benefit from this research.
What this research studies
This research investigates the role of mural cells in the remodeling of blood vessels associated with pulmonary arterial hypertension (PAH), a serious condition that can arise from congenital heart disease. The study aims to create a new animal model that closely mimics the physiological conditions of patients, allowing for a better understanding of the disease mechanisms. By exploring how increased blood flow affects vascular changes, the research seeks to identify potential new therapies that could reverse these harmful changes in patients. This approach is crucial as current treatments do not effectively halt disease progression.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve outcomes for patients with pulmonary arterial hypertension.
How similar studies have gone: While there have been studies on pulmonary hypertension, this approach of developing a novel animal model specifically tailored to mimic patient conditions is relatively novel.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Klouda, Timothy — Boston Children's Hospital
- Study coordinator: Klouda, Timothy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.