Understanding how certain cell structures contribute to the formation of calcifying particles in blood vessels.
Targeting the Caveolae-Dependent Mechanism of Calcifying Extracellular Vesicle Formation
['FUNDING_R01'] · FLORIDA INTERNATIONAL UNIVERSITY · NIH-10988240
This study is looking at how certain tiny structures in your cells might help cause harmful mineral buildup in the arteries of people with chronic kidney disease, and it hopes to find new ways to prevent or treat this problem.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FLORIDA INTERNATIONAL UNIVERSITY (nih funded) |
| Locations | 1 site (MIAMI, UNITED STATES) |
| Trial ID | NIH-10988240 on ClinicalTrials.gov |
What this research studies
This research investigates the process of vascular calcification, particularly in patients with chronic kidney disease, where mineral buildup in arteries can lead to serious cardiovascular issues. The study focuses on the role of caveolae, small invaginations in cell membranes, in the formation of calcifying extracellular vesicles (EVs) that contribute to this mineralization. By examining how these caveolae interact with other cellular components, the researchers aim to uncover new therapeutic targets to prevent or treat vascular calcification. The methodology includes tracking the formation of these EVs and their mineralization potential within vascular smooth muscle cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic kidney disease who are at risk for vascular calcification.
Not a fit: Patients without chronic kidney disease or those not experiencing vascular calcification may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce vascular calcification, improving cardiovascular health for patients with chronic kidney disease.
How similar studies have performed: While the specific mechanisms of caveolae in calcifying EV formation are not fully understood, similar research has shown promise in targeting cellular processes to mitigate vascular calcification.
Where this research is happening
MIAMI, UNITED STATES
- FLORIDA INTERNATIONAL UNIVERSITY — MIAMI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUTCHESON, JOSHUA D — FLORIDA INTERNATIONAL UNIVERSITY
- Study coordinator: HUTCHESON, JOSHUA D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.