Understanding how certain cell states affect neuroblastoma treatment outcomes
Dissecting high-risk cell states in neuroblastoma
This study is looking at how certain key proteins in neuroblastoma cancer cells affect their behavior and how they respond to chemotherapy, with the goal of finding better treatments for kids with this type of cancer.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11042175 on NIH RePORTER |
What this research studies
This research investigates the dynamic nature of cancer cells in neuroblastoma, particularly focusing on how specific master transcription factors influence cell states and their response to chemotherapy. By studying the epigenetic control of these cell states, the research aims to uncover why some neuroblastoma cells are resistant to treatment while others are not. The approach includes using advanced techniques like genome engineering and cell state reporters to analyze the relationship between cell state and chemosensitivity. This could lead to more effective, targeted therapies for children with neuroblastoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years diagnosed with neuroblastoma, particularly those with high-risk or relapsed disease.
Not a fit: Patients with neuroblastoma who are not in the high-risk category or those who are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for neuroblastoma, potentially increasing survival rates and reducing relapse in affected children.
How similar studies have performed: Other research has shown promise in understanding cancer cell states and their impact on treatment outcomes, making this approach both relevant and potentially impactful.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Durbin, Adam David — St. Jude Children's Research Hospital
- Study coordinator: Durbin, Adam David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.