Understanding how certain cell-derived particles affect nerve function in diabetes
Official title: Schwann cell-derived extracellular vesicles maintain peripheral nerve function under homeostatic conditions and promote damage in type 2 diabetes, independent of myelination
Funded at University of Michigan at Ann Arbor · NIH-10805098 · Data updated 2026-11-12
This study is looking at how tiny particles from nerve-supporting cells might help keep your nerves healthy or contribute to nerve damage if you have type 2 diabetes, and it will also explore how diet and exercise can make a difference in nerve health for people with diabetes.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | April 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $139,622 |
| NIH project number | 1K01DK135799-01A1 |
| Project ID | NIH-10805098 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 2 diabetes who are experiencing peripheral neuropathy.
✕Less likely to help
Patients without type 2 diabetes or those who do not have symptoms of peripheral neuropathy may not benefit from this research.
What this research studies
This research investigates the role of extracellular vesicles derived from Schwann cells in maintaining nerve function and how they may contribute to nerve damage in individuals with type 2 diabetes. The study aims to uncover the cellular and molecular mechanisms that lead to peripheral neuropathy, a common complication of diabetes. By using a model that mimics human diabetes conditions, researchers will explore how dietary changes and exercise can influence nerve health through these vesicles. The goal is to develop targeted therapies that can improve nerve function in diabetic patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that restore nerve function and alleviate symptoms for patients with type 2 diabetes.
How similar studies have gone: Previous research has shown promising results in understanding the role of extracellular vesicles in various conditions, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Eid, Stephanie — University of Michigan at Ann Arbor
- Study coordinator: Eid, Stephanie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.