Understanding how certain cancer cells spread in breast cancer
Mechanisms of linkage of stem and invasive phenotypes during metastatic colonization
This study is looking at how certain tough breast cancer cells can spread to other parts of the body and survive, even during treatment, to help find better ways to stop them from growing and moving around.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10907456 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which specific cancer cells in breast tumors become capable of spreading to other parts of the body, a process known as metastasis. The study focuses on a unique population of invasive cancer cells that are resistant to chemotherapy and can survive in the bloodstream. By examining how these cells interact with immune cells in the tumor environment, the research aims to uncover the biological signals that enable their migration and growth in distant organs. Patients may benefit from insights gained into how to target these aggressive cancer cells more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast cancer, particularly those with aggressive or metastatic forms of the disease.
Not a fit: Patients with early-stage breast cancer that has not spread or those with non-breast cancer conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the spread of breast cancer, potentially improving survival rates.
How similar studies have performed: Previous research has shown success in targeting specific cancer cell behaviors in other types of cancers, suggesting that this approach may yield valuable insights for breast cancer as well.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Oktay, Maja Hrzenjak — Albert Einstein College of Medicine
- Study coordinator: Oktay, Maja Hrzenjak
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.