Understanding how certain cancer cells resist treatment in ovarian cancer
Official title: Identifying Mechanisms of Resistance to SLC6AB Inhibition in CRC Liver Metastasis
Funded at Rockefeller University · NIH-11221428 · Data updated 2026-11-12
This study is looking at why some ovarian cancer patients don't respond to chemotherapy and is focusing on a protein called LIFR to find ways to help those patients get better treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $100,923 |
| NIH project number | 4K00CA284284-03 |
| Project ID | NIH-11221428 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with serous ovarian cancer who have experienced chemotherapy resistance.
✕Less likely to help
Patients with early-stage ovarian cancer who have not yet undergone chemotherapy may not benefit from this research.
What this research studies
This research investigates the mechanisms behind chemotherapy resistance in ovarian cancer, particularly focusing on the role of a protein called leukemia inhibitory factor receptor (LIFR). By analyzing tumor samples and using advanced techniques like CRISPR, the study aims to identify how LIFR contributes to treatment failure in patients. The goal is to develop strategies that could make resistant cancer cells more responsive to chemotherapy, potentially improving outcomes for patients with ovarian cancer.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the effectiveness of chemotherapy for patients with ovarian cancer.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways to overcome chemotherapy resistance in other cancers, suggesting potential for success in this area.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Ebrahimi, Behnam — Rockefeller University
- Study coordinator: Ebrahimi, Behnam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.