Understanding how certain cancer cells resist treatment in ovarian cancer
Identifying Mechanisms of Resistance to SLC6AB Inhibition in CRC Liver Metastasis
This study is looking at why some ovarian cancer patients don't respond to chemotherapy and is focusing on a protein called LIFR to find ways to help those patients get better treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11221428 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind chemotherapy resistance in ovarian cancer, particularly focusing on the role of a protein called leukemia inhibitory factor receptor (LIFR). By analyzing tumor samples and using advanced techniques like CRISPR, the study aims to identify how LIFR contributes to treatment failure in patients. The goal is to develop strategies that could make resistant cancer cells more responsive to chemotherapy, potentially improving outcomes for patients with ovarian cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with serous ovarian cancer who have experienced chemotherapy resistance.
Not a fit: Patients with early-stage ovarian cancer who have not yet undergone chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the effectiveness of chemotherapy for patients with ovarian cancer.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways to overcome chemotherapy resistance in other cancers, suggesting potential for success in this area.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Ebrahimi, Behnam — Rockefeller University
- Study coordinator: Ebrahimi, Behnam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.