Understanding how certain breast cancer cells depend on a specific enzyme
Identifying determinants of ADAR-dependency in triple-negative breast cancer
This study is looking at how a specific enzyme affects the growth of triple-negative breast cancer cells, especially in Black women who are more likely to be impacted by this type of cancer, with the goal of finding better treatments that could help them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-10999414 on NIH RePORTER |
What this research studies
This research investigates triple-negative breast cancer (TNBC), particularly its impact on Black/African American women who are disproportionately affected. The study focuses on the role of an enzyme called Adenosine Deaminase Acting on RNA (ADAR) in the growth of certain TNBC cell lines. By exploring why some cancer cells rely on ADAR for survival, the research aims to identify potential targeted therapies that could be more effective for patients, especially those from underrepresented groups. The approach includes analyzing tumor samples and cell lines to understand the mechanisms of ADAR-dependency and its relationship with interferon signaling.
Who could benefit from this research
Good fit: Ideal candidates for this research are Black/African American women diagnosed with triple-negative breast cancer.
Not a fit: Patients with other types of breast cancer or those who do not identify as Black/African American may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted treatments for triple-negative breast cancer, particularly benefiting Black/African American women.
How similar studies have performed: This research builds on previous findings that suggest targeting ADAR may be effective, particularly in populations with higher interferon signaling, indicating a promising but still developing area of study.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Cottrell, Kyle — Purdue University
- Study coordinator: Cottrell, Kyle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.