Understanding how certain breast cancer cells change and become more aggressive
The Role of Dedifferentiation in Basal like Breast Cancer
This study is looking at how certain aggressive breast cancer cells change and become tougher to treat, with the hope of finding new ways to help people with Basal-like Breast Cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10925261 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the transformation of breast cancer cells, particularly focusing on Basal-like Breast Cancer (BLBC), which is known for its aggressive nature. By studying the cellular changes and the role of specific proteins, the research aims to identify the origins of these cancer cells and how they gain the ability to become more versatile and resistant to treatment. The approach includes advanced techniques like single-cell RNA sequencing to analyze the genetic activity of cells in a mouse model that mimics human breast cancer. This could lead to better understanding and potentially new strategies for treating this challenging type of breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Basal-like Breast Cancer or Triple Negative Breast Cancer.
Not a fit: Patients with non-aggressive forms of breast cancer or those without a diagnosis of breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with aggressive breast cancer types.
How similar studies have performed: Other research has shown promise in understanding cellular plasticity in cancer, but this specific approach focusing on BLBC is relatively novel.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Larios-Valencia, Jessie — Albert Einstein College of Medicine
- Study coordinator: Larios-Valencia, Jessie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.