Understanding how certain brain tumors depend on a specific metabolic pathway for survival
Dissecting Mechanisms of Pyrimidine Synthesis Dependence in IDH Mutant Glioma
['FUNDING_FELLOWSHIP'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11083030
This study is looking at how certain changes in genes affect lower-grade brain tumors and how these changes make the tumors depend on a specific process to survive, with the goal of finding new treatment options for patients.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11083030 on ClinicalTrials.gov |
What this research studies
This research investigates the role of IDH mutations in lower-grade gliomas, a type of brain tumor, and how these mutations create a reliance on a specific pathway for producing pyrimidine nucleotides, which are essential for cell survival. By profiling the metabolism of patient-derived glioma stem-like cells, the research aims to uncover the mechanisms behind this dependence and identify potential new therapeutic targets. The approach involves treating these cells with inhibitors and analyzing their metabolic responses to better understand the vulnerabilities of IDH mutant gliomas.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with lower-grade gliomas that have IDH mutations.
Not a fit: Patients with gliomas that do not have IDH mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that specifically target the metabolic vulnerabilities of IDH mutant gliomas, potentially improving outcomes for patients with these tumors.
How similar studies have performed: Previous research has shown that targeting metabolic pathways in cancer cells can lead to successful therapeutic strategies, suggesting that this approach may also yield promising results.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SAVANI, MILAN RASHMIN — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: SAVANI, MILAN RASHMIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.