Understanding how certain brain receptors influence cocaine addiction
Kappa Opioid Receptors and Phospho-Dopamine Transporters Drive Cocaine Reward
This study is looking into how certain brain receptors related to cocaine use might affect addiction, with the goal of finding new ways to help people who are dealing with cocaine addiction.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-10877836 on NIH RePORTER |
What this research studies
This research investigates the complex neurobiology of cocaine use disorder (CUD) by focusing on the role of kappa opioid receptors and phospho-dopamine transporters in the brain. It aims to uncover how these receptors affect dopamine signaling and the rewarding effects of cocaine. Using advanced techniques, including genetically modified mouse models and targeted brain interventions, the study seeks to identify potential new pathways for treatment. By understanding these mechanisms, the research hopes to pave the way for developing effective medications for individuals struggling with cocaine addiction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cocaine use disorder who are seeking treatment options.
Not a fit: Patients who are not struggling with cocaine addiction or those with other substance use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new medications that effectively treat cocaine addiction.
How similar studies have performed: While the specific focus on post-translational modifications in cocaine addiction is novel, similar approaches in understanding addiction mechanisms have shown promise in other substance use disorders.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Ramamoorthy, Sammanda — Virginia Commonwealth University
- Study coordinator: Ramamoorthy, Sammanda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.