Understanding how certain brain receptors are regulated by cell adhesion molecules
Elucidating transsynaptic regulation of metabotropic glutamate receptors
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF FLORIDA · NIH-11000253
This study is looking at how certain brain proteins work together to keep glutamate levels balanced, which is important for thinking and movement, and it hopes to find ways to help prevent problems like epilepsy and movement disorders.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-11000253 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between metabotropic glutamate receptors and cell-adhesion molecules in the brain. It aims to understand how these interactions help regulate glutamate levels, which are crucial for cognitive and motor functions. By studying these mechanisms, the research seeks to uncover the role of these proteins in maintaining synaptic health and preventing disorders like epilepsy and movement issues. The approach includes examining the binding and stabilization of these receptors through advanced techniques.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that involve glutamate dysregulation, such as epilepsy or movement disorders.
Not a fit: Patients with conditions unrelated to glutamate signaling or those without neurological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into treating neurological disorders related to glutamate dysregulation.
How similar studies have performed: Previous research has shown promising results in understanding GPCR regulation, indicating that this approach has potential for success.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LUDLAM, WILLIAM GRANT — UNIVERSITY OF FLORIDA
- Study coordinator: LUDLAM, WILLIAM GRANT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.