Understanding how certain brain receptors are regulated by cell adhesion molecules
Official title: Elucidating transsynaptic regulation of metabotropic glutamate receptors
Funded at University of Florida · NIH-11000253 · Data updated 2026-11-12
This study is looking at how certain brain proteins work together to keep glutamate levels balanced, which is important for thinking and movement, and it hopes to find ways to help prevent problems like epilepsy and movement disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $74,284 |
| NIH project number | 5F32NS124758-03 |
| Project ID | NIH-11000253 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological conditions that involve glutamate dysregulation, such as epilepsy or movement disorders.
✕Less likely to help
Patients with conditions unrelated to glutamate signaling or those without neurological disorders may not benefit from this research.
What this research studies
This research investigates the interactions between metabotropic glutamate receptors and cell-adhesion molecules in the brain. It aims to understand how these interactions help regulate glutamate levels, which are crucial for cognitive and motor functions. By studying these mechanisms, the research seeks to uncover the role of these proteins in maintaining synaptic health and preventing disorders like epilepsy and movement issues. The approach includes examining the binding and stabilization of these receptors through advanced techniques.
Why it matters
Potential benefit: If successful, this research could lead to new insights into treating neurological disorders related to glutamate dysregulation.
How similar studies have gone: Previous research has shown promising results in understanding GPCR regulation, indicating that this approach has potential for success.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Ludlam, William Grant — University of Florida
- Study coordinator: Ludlam, William Grant
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.