Understanding how certain brain receptors affect alcohol use disorders
The Role of Kappa-Opioid Receptors in Alcohol Use Disorders
This study is looking at how certain brain receptors are influenced by long-term drinking and how this might make it harder for people with alcohol use problems to control their drinking, with the hope of finding new ways to help them manage their alcohol dependence.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10473825 on NIH RePORTER |
What this research studies
This research investigates the role of kappa-opioid receptors in the brain and how they are affected by chronic alcohol consumption. It aims to understand the neurobiological changes that occur in individuals with alcohol use disorders, particularly focusing on how these changes may lead to increased alcohol intake and difficulty in controlling consumption. By examining the relationship between negative emotions and alcohol use, the research seeks to identify potential therapeutic targets for better treatment options. Patients may benefit from insights that could lead to new strategies for managing alcohol dependence.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcohol use disorders who may also experience negative affective states such as depression or anxiety.
Not a fit: Patients who do not have alcohol use disorders or those who are not experiencing any related psychological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for individuals struggling with alcohol use disorders.
How similar studies have performed: Previous research has shown promising results in understanding the neurobiological mechanisms of alcohol use disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Walker, Brendan M — University of South Florida
- Study coordinator: Walker, Brendan M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.