Understanding how certain brain chemicals affect memory in aging and Alzheimer's disease
Catecholaminergic Signaling in Normal Cognition, Aging and Models of Alzheimer's Disease
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10875743
This study is looking at how certain brain chemicals, like dopamine and norepinephrine, affect memory as we age and in people with Alzheimer's, using animal models to see how changes in these chemicals might help us understand memory problems better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10875743 on ClinicalTrials.gov |
What this research studies
This research investigates the role of catecholaminergic signaling, specifically dopamine and norepinephrine, in memory processes related to aging and Alzheimer's disease. By using rodent models, the study aims to explore how these neurotransmitters influence memory encoding and retrieval, particularly in the hippocampus, which is crucial for forming memories. The researchers will employ pharmacological and genetic techniques to manipulate these signaling pathways and assess their effects on memory performance. This approach could provide insights into the underlying mechanisms of memory impairment associated with aging and Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing memory issues or individuals diagnosed with Alzheimer's disease.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving memory function in patients with Alzheimer's disease and age-related cognitive decline.
How similar studies have performed: Previous research has shown promising results in understanding the role of neurotransmitters in memory, suggesting that this approach could yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: THOMAS, STEVEN A — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: THOMAS, STEVEN A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.