Understanding how certain brain cells maintain their growth and survival
The role of membrane homoeostasis of neural stem cell and glioma stem cells in neural development and gliomagenesis
['FUNDING_R01'] · UNIVERSITY OF TX MD ANDERSON CAN CTR · NIH-11097256
This study is looking at how certain brain tumor cells, called glioma stem cells, keep growing even in tough conditions, and it focuses on a protein that might help us find new ways to treat glioblastoma, the most aggressive type of brain tumor, so that patients can have better treatment options.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TX MD ANDERSON CAN CTR (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11097256 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which glioma stem cells (GSCs) maintain their ability to grow and self-renew, particularly in challenging environments outside their normal niches. It focuses on the role of a specific protein, Quaking (QKI), which regulates important cellular processes like receptor signaling and membrane composition. By studying these processes, the research aims to uncover potential therapeutic targets that could help in treating glioblastoma, the most aggressive form of brain tumor. Patients may benefit from insights that could lead to new treatment strategies for brain tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with glioblastoma or those at risk of developing brain tumors.
Not a fit: Patients with non-cancerous brain conditions or those without any neurological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve outcomes for patients with glioblastoma.
How similar studies have performed: Previous research has shown promising results in targeting similar cellular mechanisms in cancer treatment, indicating potential for success in this approach.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TX MD ANDERSON CAN CTR — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HU, JIAN — UNIVERSITY OF TX MD ANDERSON CAN CTR
- Study coordinator: HU, JIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.