Understanding how certain brain cells die during eye development
Mechanisms of naturally-occurring astrocyte death during retinal development
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11043310
This study is looking at how certain brain cells in the eye die during its development and how other brain cells help with this process, which could help us understand eye health and similar issues in diseases that affect the brain.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11043310 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind the death of retinal astrocytes, a type of brain cell, during the development of the eye. It focuses on how microglia, another type of brain cell, contribute to this process by responding to signals from astrocytes. By identifying the specific microglial cells involved and the molecular signals that trigger this cell death, the research aims to uncover how these processes affect the formation of blood vessels in the retina. This knowledge could also provide insights into similar mechanisms in neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting retinal development or neurodegenerative diseases.
Not a fit: Patients with stable retinal conditions that do not involve developmental issues or neurodegeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating retinal diseases and improving vision.
How similar studies have performed: Other research has shown success in understanding cell death mechanisms in the nervous system, suggesting that this approach may yield valuable insights.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAY, JEREMY N — DUKE UNIVERSITY
- Study coordinator: KAY, JEREMY N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.