Understanding how certain brain cells develop into oligodendrocytes
The Role of Notch Signaling in Shh-mediated Oligodendrocyte Fate Specification
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF COLORADO DENVER · NIH-10997313
This study is looking at how certain signals in the brain help stem cells decide to become specific types of cells, like those that support nerve function, instead of becoming nerve cells, which could help us understand brain development and diseases related to myelin.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10997313 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that guide neural progenitor cells in the brain to differentiate into oligodendrocyte precursor cells (OPCs) instead of neurons during development. By focusing on the role of Sonic hedgehog (Shh) signaling and the Notch pathway, the study aims to uncover the molecular processes that influence this transition. Using advanced techniques like single-cell RNA sequencing, researchers will analyze how these signals affect cell fate decisions in the developing mouse brain. The findings could provide insights into the fundamental biology of brain development and potential implications for diseases affecting myelin.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that involve oligodendrocyte dysfunction or myelin loss.
Not a fit: Patients with conditions unrelated to oligodendrocyte development or myelin formation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating conditions related to myelin damage, such as multiple sclerosis.
How similar studies have performed: Previous research has shown success in understanding cell signaling pathways in brain development, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TRAN, LUULI — UNIVERSITY OF COLORADO DENVER
- Study coordinator: TRAN, LUULI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.