Understanding how certain brain cells control crying in newborn mice
Dissecting the modulatory function of hypothalamic neurons in the temporarily restricted emission of vocalizations by neonatal mice
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10865085
This study looks at how certain brain cells in baby mice help them make sounds, like crying, to get their caregivers' attention, and it aims to understand how these cells work together to control these important vocalizations.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10865085 on ClinicalTrials.gov |
What this research studies
This research investigates how specific neurons in the hypothalamus of neonatal mice influence their vocalizations, particularly crying, which is crucial for attracting caregiver attention. By examining the roles of two types of neurons that produce different proteins, the study aims to uncover the neural circuits involved in this behavior. The researchers will employ advanced techniques in neuroscience to explore how these neurons interact and regulate vocal behavior in young mice. The findings could provide insights into the neurobiological mechanisms underlying vocalization in mammals.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with neurodevelopmental disorders characterized by atypical vocal behaviors, such as autism and Angelman syndrome.
Not a fit: Patients with vocalization disorders not related to neurodevelopmental conditions or those outside the neonatal age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of vocalization disorders in humans, potentially leading to better interventions for conditions like autism and Angelman syndrome.
How similar studies have performed: While the specific focus on neonatal vocalization modulation is novel, related research has successfully explored the role of brain circuits in behavior control.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DIETRICH, MARCELO — YALE UNIVERSITY
- Study coordinator: DIETRICH, MARCELO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Angelman Syndrome, Autistic Disorder