Understanding how certain brain cells connect reproduction and body weight
Characterization of Kiss1 neurons as mediators of the reproductive regulation of energy balance
This research explores how specific brain cells called Kiss1 neurons help control both our reproductive system and how our bodies manage energy, which affects body weight.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11123125 on NIH RePORTER |
What this research studies
Our bodies carefully balance reproduction and energy use to stay healthy. This project focuses on special brain cells, called Kiss1 neurons, that seem to play a key role in this balance. We are learning how these Kiss1 neurons interact with other brain signals, like melanocortins, which are known to influence feelings of fullness and how much energy our body burns. By understanding these connections, we hope to uncover how these brain circuits contribute to maintaining a healthy body weight and reproductive function.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but future studies building on these findings might seek individuals with metabolic or reproductive imbalances.
Not a fit: Patients seeking immediate treatment options will not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to understand and potentially treat conditions related to obesity or reproductive health issues.
How similar studies have performed: Preliminary data from this team and other animal models suggest that kisspeptin signaling is involved in metabolism, indicating this work builds on existing knowledge while exploring novel connections.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Navarro, Victor Manuel — Brigham and Women's Hospital
- Study coordinator: Navarro, Victor Manuel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.