Understanding how certain brain cells communicate in psychiatric and neurological disorders
Molecular basis of glutamatergic synapse function in inhibitory interneurons
This study is looking at how certain proteins in special brain cells help them communicate with each other, which could help us understand more about brain disorders that affect mood and behavior.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10872127 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind glutamatergic synapses in inhibitory interneurons, which are crucial for brain function. By identifying specific proteins that are unique to these neurons, the study aims to uncover how these proteins influence synaptic communication. The approach involves advanced techniques like immunoisolation and mass spectrometry to analyze the molecular composition of these synapses. This research could provide insights into the biological underpinnings of various psychiatric and neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with psychiatric or neurological disorders that may be associated with glutamatergic synapse dysfunction.
Not a fit: Patients with conditions unrelated to glutamatergic synapse function or those without psychiatric or neurological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating psychiatric and neurological disorders linked to synaptic dysfunction.
How similar studies have performed: Other research has shown promising results in understanding synaptic function through similar molecular approaches, indicating potential for success in this area.
Where this research is happening
Boston, United States
- Tufts University Boston — Boston, United States (Active)
Researchers
- Principal investigator: Bygrave, Alexei Mansfield — Tufts University Boston
- Study coordinator: Bygrave, Alexei Mansfield
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.