Understanding how certain brain cells communicate and behave in autism
Origin, Mechanism, and Behavioral Context of Persistent Firing in Cortical Parvalbumin-Positive Interneurons
This study is looking at special brain cells that help with communication in the brain to understand a unique way they send signals, which might be connected to autism, and the goal is to learn more about how these cells work to help improve our understanding of autism and similar conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10872223 on NIH RePORTER |
What this research studies
This research investigates the behavior of specific brain cells known as parvalbumin-positive interneurons, which play a crucial role in communication within the brain. The study aims to uncover the mechanisms behind a unique firing pattern of these cells, known as ectopic firing, which may be linked to conditions like autism. By using advanced imaging techniques, researchers will track how these cells send signals and what factors influence their behavior. The findings could provide insights into the cellular processes that contribute to autism and related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder (ASD) or related neurodevelopmental conditions.
Not a fit: Patients with conditions unrelated to autism or those without neurodevelopmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new understanding and potential treatments for autism and related brain disorders.
How similar studies have performed: While the specific focus on ectopic firing in parvalbumin-positive interneurons is novel, similar research has shown promising results in understanding neuronal behavior in various brain disorders.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Theyel, Brian — Brown University
- Study coordinator: Theyel, Brian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.