Understanding how certain brain cells cause nausea and vomiting
Molecular and circuit mechanisms of nausea-associated behaviors
This study is looking at how a part of the brain that helps us feel nauseous works, with the hope of finding better ways to help people who feel sick, especially those dealing with conditions like cancer or diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10929524 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind nausea, particularly focusing on a specific area of the brain known as the area postrema, which plays a crucial role in sensing nausea-inducing signals. By using advanced techniques like single-nucleus RNA sequencing and genetic studies, the researchers aim to identify how certain neurons in this area respond to various cues that trigger nausea. The goal is to better understand the biological pathways involved in nausea, which could lead to improved treatments for patients experiencing nausea as a side effect of conditions like cancer or diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who experience nausea as a side effect of treatments for conditions such as cancer or diabetes.
Not a fit: Patients who do not experience nausea or who have conditions unrelated to nausea may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for nausea, improving the quality of life for patients undergoing various medical treatments.
How similar studies have performed: Previous research has shown promise in understanding the mechanisms of nausea, but this specific approach focusing on the area postrema is relatively novel.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Zhang, Chuchu — University of California Los Angeles
- Study coordinator: Zhang, Chuchu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.