Understanding how certain brain cells are affected in Parkinson's disease
Official title: Profiling of Midbrain Neuronal Vulnerability in Parkinson's Disease
Funded at Icahn School of Medicine at Mount Sinai · NIH-11071321 · Data updated 2026-11-12
This study is looking at how certain brain cells are affected in people with Parkinson's disease, and it hopes to find new ways to improve treatments by analyzing samples from patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 1, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 1F31NS137751-01A1 |
| Project ID | NIH-11071321 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have been diagnosed with Parkinson's disease.
✕Less likely to help
Patients with early-stage Parkinson's disease or those without a confirmed diagnosis may not receive direct benefits from this research.
What this research studies
This research investigates the vulnerability of specific types of neurons in the midbrain of individuals with Parkinson's disease (PD). By using advanced techniques like single-nucleus RNA sequencing, the study aims to identify and characterize unique populations of neurons that may be affected by the disease. The goal is to better understand the cellular changes that occur in PD, which could lead to improved treatment strategies. Patients may be involved in providing biological samples to help researchers analyze these neuronal populations.
Why it matters
Potential benefit: If successful, this research could lead to new insights into Parkinson's disease, potentially improving diagnosis and treatment options for patients.
How similar studies have gone: Previous research using similar techniques has shown promise in understanding neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Liang, Marianna — Icahn School of Medicine at Mount Sinai
- Study coordinator: Liang, Marianna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.