Understanding how certain brain cells are affected in Alzheimer's disease
Official title: CA1 cell-type susceptibility in Alzheimer's
Funded at University of Southern California · NIH-10891017 · Data updated 2026-11-12
This study is looking at how certain brain cells in an area important for memory are affected by Alzheimer's disease, with the goal of finding ways to help people at risk for the disease before they start having memory problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | August 1, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $51,652 |
| NIH project number | 1R36AG087310-01 |
| Project ID | NIH-10891017 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who show early signs of amyloid and tau pathology but have not yet developed cognitive impairment.
✕Less likely to help
Patients who are already diagnosed with advanced Alzheimer's disease or those without any amyloid or tau pathology may not benefit from this research.
What this research studies
This research investigates the vulnerability of specific brain cells in the medial temporal lobe (MTL) to Alzheimer's disease (AD) pathology. Using advanced neuroimaging and molecular techniques, the study aims to identify how amyloid and tau proteins affect CA1 neurons, which are crucial for memory. By understanding these changes, researchers hope to pinpoint early intervention targets that could prevent or slow down the progression of cognitive impairment in individuals at risk for AD.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for early treatment of Alzheimer's disease, potentially delaying or preventing cognitive decline.
How similar studies have gone: Previous research has shown promise in identifying vulnerable brain regions in Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Pachicano, Maricarmen — University of Southern California
- Study coordinator: Pachicano, Maricarmen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.