Understanding how certain brain cells are affected by tau protein in Alzheimer's disease
Mechanisms of Susceptibility of Excitatory Neurons to Tau Pathology and Neurodegeneration in Alzheimer's disease
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-10764312
This study is looking into why certain brain cells in people with Alzheimer's disease are more likely to get damaged by a harmful protein, with the hope of finding new ways to protect these cells and improve treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10764312 on ClinicalTrials.gov |
What this research studies
This research investigates the reasons why specific excitatory neurons in the hippocampus are particularly vulnerable to tau protein accumulation and neurodegeneration in Alzheimer's disease. By using advanced techniques like single cell RNA sequencing and viral translating ribosome affinity purification, the study aims to identify the molecular pathways that lead to the damage of these neurons. The findings could help in understanding the progression of Alzheimer's and in finding new therapeutic targets to protect these vulnerable cells. Patients may benefit from insights that could lead to innovative treatments for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to tau pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that protect brain cells from damage in Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in understanding tau pathology, but this approach using single cell techniques is relatively novel.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PEREIRA, ANA C. — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: PEREIRA, ANA C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease