Understanding how certain brain cells are affected by Alzheimer's disease
Official title: Mathematical modeling of selective vulnerability of genes, cells and network in mouse tauopathy
Funded at University of California, San Francisco · NIH-10884976 · Data updated 2026-11-12
This study is looking into why some parts of the brain are more affected by Alzheimer's disease than others, using smart math tools to understand how certain brain cells and proteins play a role in this, so we can better understand the disease and help those who are living with it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $2,138,027 |
| NIH project number | 1RF1AG087302-01 |
| Project ID | NIH-10884976 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research investigates why specific regions of the brain are more vulnerable to Alzheimer's disease by using advanced mathematical modeling techniques. It aims to explore the cellular and network-level factors that contribute to the progression of the disease, focusing on how protein aggregation and the characteristics of certain neural cells influence vulnerability. By analyzing data from single-cell sequencing and spatial transcriptomics, the study seeks to validate hypotheses about the mechanisms behind selective vulnerability in Alzheimer's pathology.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of Alzheimer's disease, potentially guiding the development of targeted therapies.
How similar studies have gone: Previous research has shown promise in understanding selective vulnerability in Alzheimer's disease, but this approach using mathematical modeling is relatively novel.
Where this research is happening
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University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Raj, Ashish — University of California, San Francisco
- Study coordinator: Raj, Ashish
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.