Understanding how certain blood mutations may protect against Alzheimer's disease
Uncovering mechanisms of protection from Alzheimer's disease in CHIP using human cohorts and biosamples
This study is looking at how certain changes in blood stem cells, which are often found in older adults, might help protect against Alzheimer's disease, and it's for anyone interested in understanding how these changes could influence brain health as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11193530 on NIH RePORTER |
What this research studies
This research investigates the relationship between clonal hematopoiesis of indeterminate potential (CHIP) and Alzheimer's disease. It focuses on how mutations in blood stem cells, which are common in older adults, might influence the risk of developing Alzheimer's. By analyzing human cohorts and biosamples, the study aims to uncover the mechanisms behind the observed protective effects of CHIP against Alzheimer's disease. Patients with CHIP may have altered immune responses in the brain that could be beneficial in preventing Alzheimer's-related damage.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults with clonal hematopoiesis of indeterminate potential (CHIP) who are at risk for Alzheimer's disease.
Not a fit: Patients without CHIP or those who are not at risk for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease.
How similar studies have performed: Previous epidemiological studies have shown a protective association between CHIP and Alzheimer's disease, suggesting that this research builds on promising findings.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Jaiswal, Siddhartha — Stanford University
- Study coordinator: Jaiswal, Siddhartha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.