Understanding how certain blood factors work together to prevent bleeding
Translating Mechanistic Insights into Intrinsic Xase Function
This study is looking at a special enzyme that helps your blood clot, and it's aimed at finding better treatments for people with bleeding disorders like hemophilia A and B, especially those with certain genetic differences.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10768832 on NIH RePORTER |
What this research studies
This research investigates the intrinsic Xase enzyme complex, which plays a crucial role in blood clotting. It focuses on understanding the structure and function of key components involved in coagulation, particularly in patients with bleeding disorders like hemophilia A and B. The researchers aim to develop new therapeutic approaches that could improve treatment options for these conditions, especially for patients with specific genetic variants. By studying how these factors interact, the research seeks to enhance the effectiveness of existing treatments and potentially create new ones.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with hemophilia A or B, particularly those with specific genetic variants affecting their coagulation factors.
Not a fit: Patients without bleeding disorders or those whose conditions do not involve the intrinsic Xase enzyme complex may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with bleeding disorders, reducing the burden of current therapies.
How similar studies have performed: Previous research has shown promise in developing therapies targeting similar mechanisms in blood coagulation disorders, indicating a potential for success in this approach.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Samelson-Jones, Ben J — Children's Hosp of Philadelphia
- Study coordinator: Samelson-Jones, Ben J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.