Understanding how certain blood factors affect mechanical circulation
The role of contact pathway factors in mechanical circulation
This study is looking at how a specific blood factor called factor XII affects blood clotting and inflammation in patients who need special heart and lung support, like ECMO or CPB, to help find better ways to manage bleeding and clotting risks during these important treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10887510 on NIH RePORTER |
What this research studies
This research investigates the role of specific blood coagulation factors, particularly factor XII, in the thromboinflammatory responses associated with mechanical circulatory support methods like ECMO and CPB. The study aims to explore how these factors contribute to both thrombosis and inflammation during these procedures, which are critical for patients with severe cardiac and respiratory failure. By examining the mechanisms of factor XII activation and its interactions with other components of the coagulation system, the research seeks to identify potential new strategies for managing bleeding and clotting risks in patients undergoing mechanical support. The findings could lead to improved anticoagulation therapies tailored for patients receiving these life-saving interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients requiring mechanical circulatory support, such as those undergoing ECMO or CPB due to severe cardiac or respiratory conditions.
Not a fit: Patients who are not undergoing mechanical circulatory support or those with conditions unrelated to blood coagulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective anticoagulation strategies for patients undergoing mechanical circulatory support.
How similar studies have performed: While the role of factor XII in coagulation is known, this specific investigation into its effects during mechanical circulation is relatively novel and has not been extensively studied.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Palumbo, Joseph S. — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Palumbo, Joseph S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.