Understanding how certain blood cells can change into different types.
Mechanisms of lineage plasticity revealed by YY1 deficiency.
This study is looking at how a protein called YY1 influences the development of blood cells, especially B and T cells, using a special mouse model to see what happens when YY1 is missing, which could help us understand blood cell growth better and find new treatments for blood-related diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11089421 on NIH RePORTER |
What this research studies
This research investigates how a specific transcription factor, YY1, affects the commitment of blood cells to their lineages, particularly focusing on B and T cells. By using a specially designed mouse model, the researchers aim to explore how the absence of YY1 allows B cells to revert to a more primitive state or even transform into T cells. This study will provide insights into the mechanisms of blood cell development and the potential for lineage flexibility, which could have implications for therapies in blood-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with blood disorders or conditions affecting B and T cell development.
Not a fit: Patients with stable blood cell lineages and no history of blood disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating blood disorders by harnessing the ability of blood cells to change their lineage.
How similar studies have performed: While the concept of lineage plasticity is being explored, this specific approach focusing on YY1 deficiency is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Atchison, Michael Lee — University of Pennsylvania
- Study coordinator: Atchison, Michael Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.