Understanding how certain bladder cells develop and help repair kidney damage in children
Defining the renal urothelium progenitor and its regulation during development and repair
['FUNDING_CAREER'] · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · NIH-11093476
This study is looking at special bladder cells in kids with urinary tract blockages to understand how they help the kidneys grow and heal, with the hope of finding new ways to prevent kidney problems in the future.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RESEARCH INST NATIONWIDE CHILDREN'S HOSP (nih funded) |
| Locations | 1 site (COLUMBUS, UNITED STATES) |
| Trial ID | NIH-11093476 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific bladder cells, known as K5-expressing urothelial cells, in the development and repair of the kidneys, particularly in children with congenital urinary tract obstruction (UTO). The study aims to uncover the molecular mechanisms that control these cells' behavior during kidney injury and development. By examining how these cells contribute to kidney health, the research seeks to identify potential new therapies to prevent chronic kidney disease progression in affected children. The approach includes both laboratory studies and analysis of cellular behavior in response to injury.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who have been diagnosed with congenital urinary tract obstruction.
Not a fit: Patients with kidney issues unrelated to urinary tract obstruction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent kidney damage and improve outcomes for children with urinary tract obstructions.
How similar studies have performed: Previous research has shown promising results in understanding bladder cell behavior in kidney health, suggesting that this approach could yield valuable insights.
Where this research is happening
COLUMBUS, UNITED STATES
- RESEARCH INST NATIONWIDE CHILDREN'S HOSP — COLUMBUS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JACKSON, ASHLEY R. — RESEARCH INST NATIONWIDE CHILDREN'S HOSP
- Study coordinator: JACKSON, ASHLEY R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.