Understanding how certain bacteria survive in a dormant state
Investigating the viable but not culturable (VBNC) state in P. gingivalis
['FUNDING_R01'] · UNIVERSITY OF FLORIDA · NIH-10745659
This study is looking at how a type of bacteria called P. gingivalis can go into a sleepy state where they’re still alive but can’t be grown in a lab, and it aims to find out how to wake them up and understand their role in gum diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-10745659 on ClinicalTrials.gov |
What this research studies
This research investigates how the bacteria P. gingivalis can enter a dormant state where they are alive but cannot be cultured in a lab. The study aims to explore the genetic and metabolic characteristics of this viable but non-culturable (VBNC) state and how these bacteria can be resuscitated. By identifying specific genes and biomarkers associated with this state, the research seeks to understand the role of P. gingivalis in chronic infections, particularly periodontal diseases. The approach includes both laboratory experiments and animal models to assess the impact of these genes on bacterial behavior and virulence.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic periodontal diseases or those at risk of such infections.
Not a fit: Patients who do not have periodontal diseases or are not at risk for such conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment of chronic periodontal diseases caused by P. gingivalis.
How similar studies have performed: Previous research has shown success in understanding bacterial survival mechanisms, but the specific focus on the VBNC state of P. gingivalis is relatively novel.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PROGULSKE-FOX, ANN — UNIVERSITY OF FLORIDA
- Study coordinator: PROGULSKE-FOX, ANN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Infection