Understanding how certain bacteria resist common antibiotics
Intrinsic modifiers of beta-lactam resistance in nosocomial Enterobacterales
['FUNDING_CAREER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10993591
This study is looking at how certain bacteria that can cause infections in hospital patients become resistant to common antibiotics, so we can find better ways to use these medicines and develop new ones.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10993591 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind antibiotic resistance in a group of bacteria known as Enterobacterales, which are often responsible for infections in hospitalized patients. The project aims to identify specific proteins that contribute to resistance against beta-lactam antibiotics, a common class of antibiotics. Through laboratory experiments and advanced techniques like quantitative proteomics, the researchers will explore how these proteins function and how mutations can lead to resistance. The findings could help inform better antibiotic use in clinical settings and identify new targets for antibiotic development.
Who could benefit from this research
Good fit: Ideal candidates for this research are hospitalized patients who are infected with antibiotic-resistant bacteria, particularly those in need of treatment for infections caused by Enterobacterales.
Not a fit: Patients with infections caused by bacteria that are not part of the Enterobacterales group may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for antibiotic-resistant infections, potentially saving lives.
How similar studies have performed: Previous research has shown success in understanding antibiotic resistance mechanisms, but this specific approach focusing on intrinsic resistance in Enterobacterales is relatively novel.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAZARUS, JACOB ERIC — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: LAZARUS, JACOB ERIC
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.