Understanding how certain bacteria resist antibiotics and affect patient outcomes
Mechanisms of Resistance and Clinical Outcomes of non-Carbapenemase Producing Carbapenem-Resistant Klebsiella pneumoniae Infections
This study is looking at how certain tough-to-treat infections caused by Klebsiella pneumoniae bacteria work, so we can learn more about them and find better ways to help patients recover.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11112656 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind non-carbapenemase producing carbapenem-resistant Klebsiella pneumoniae (NCP-Kpn) infections, which are increasingly common and pose a significant health threat. The study aims to gather clinical data on the outcomes of these infections, focusing on how changes in bacterial structure affect antibiotic effectiveness. By analyzing the genetic and biochemical characteristics of these bacteria, researchers hope to identify patterns that could inform better treatment strategies. Patients with these infections may be monitored to understand their responses to different antibiotics and improve future care.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 who are infected with non-carbapenemase producing carbapenem-resistant Klebsiella pneumoniae.
Not a fit: Patients with infections caused by carbapenemase-producing Klebsiella pneumoniae may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better management of infections caused by antibiotic-resistant bacteria.
How similar studies have performed: While research on carbapenem-resistant bacteria is ongoing, the specific focus on non-carbapenemase producing strains is relatively novel and has not been extensively studied.
Where this research is happening
Houston, United States
- Methodist Hospital Research Institute — Houston, United States (Active)
Researchers
- Principal investigator: Miller, William R — Methodist Hospital Research Institute
- Study coordinator: Miller, William R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.