Understanding how certain bacteria resist antibiotics and affect patient outcomes
Official title: Mechanisms of Resistance and Clinical Outcomes of non-Carbapenemase Producing Carbapenem-Resistant Klebsiella pneumoniae Infections
Funded at Methodist Hospital Research Institute · NIH-11112656 · Data updated 2026-11-12
This study is looking at how certain tough-to-treat infections caused by Klebsiella pneumoniae bacteria work, so we can learn more about them and find better ways to help patients recover.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $259,461 |
| NIH project number | 1R21AI190338-01 |
| Project ID | NIH-11112656 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 who are infected with non-carbapenemase producing carbapenem-resistant Klebsiella pneumoniae.
✕Less likely to help
Patients with infections caused by carbapenemase-producing Klebsiella pneumoniae may not benefit from this research.
What this research studies
This research investigates the mechanisms behind non-carbapenemase producing carbapenem-resistant Klebsiella pneumoniae (NCP-Kpn) infections, which are increasingly common and pose a significant health threat. The study aims to gather clinical data on the outcomes of these infections, focusing on how changes in bacterial structure affect antibiotic effectiveness. By analyzing the genetic and biochemical characteristics of these bacteria, researchers hope to identify patterns that could inform better treatment strategies. Patients with these infections may be monitored to understand their responses to different antibiotics and improve future care.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better management of infections caused by antibiotic-resistant bacteria.
How similar studies have gone: While research on carbapenem-resistant bacteria is ongoing, the specific focus on non-carbapenemase producing strains is relatively novel and has not been extensively studied.
Where this research is happening
-
Methodist Hospital Research Institute
Houston, United States Active
Researchers
- Principal investigator: Miller, William R — Methodist Hospital Research Institute
- Study coordinator: Miller, William R
Related research
Other NIH-funded projects on the same topics.
-
Investigating how DNA damage and repair mechanisms are altered in ALS and frontotemporal dementia.
This study is looking at how problems with DNA repair might contribute to conditions like ALS and frontotemporal dementia, and it’s testing ways to fix these issues in cells from patients to help develop new treatments.
-
Cefazolin Inoculum Effect and MSSA Bacteremia: A Rapid Test to Guide Therapy
A study to understand how a high bacterial load affects cefazolin treatment for serious Staphylococcus aureus infections and to test a quick lab method that helps doctors choose the best antibiotic.
-
Cefazolin Inoculum Effect: How this test could improve care for MSSA bloodstream infections
This project tests a quick lab test to find a specific cefazolin resistance pattern in MSSA blood infections so doctors can choose safer, more effective treatment.
-
Vascularized niche with local immune protection to transplant insulin-producing cells for Type 1 diabetes
A new approach aims to transplant insulin-producing cells inside a vascularized pocket with local drug delivery to keep them alive and functioning without full-body immune suppression.
-
How brain connections guide visual choices in ADHD
A research study aims to understand how specific brain pathways help people with ADHD make visual decisions, using non-invasive methods in primates.
-
Why some Klebsiella pneumoniae infections resist key carbapenem antibiotics
This project looks at why certain Klebsiella pneumoniae infections resist carbapenem antibiotics and how those infections affect adult patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.