Understanding how certain bacteria resist antibiotics
Role and regulation of peptidoglycan synthases in enterococcal antimicrobial resistance
This study is looking at how certain bacteria, called enterococci, become resistant to antibiotics, which can help us find new ways to treat infections in patients who are dealing with these tough germs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10782441 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind antibiotic resistance in enterococci, which are bacteria that can cause serious hospital-acquired infections. The study focuses on specific enzymes involved in the synthesis of the bacterial cell wall, which are crucial for the bacteria's ability to resist commonly used antibiotics like cephalosporins. By exploring the genetic and biochemical pathways that regulate these enzymes, the research aims to identify new targets for developing effective antimicrobial therapies. Patients may benefit from this work as it could lead to better treatment options for infections caused by antibiotic-resistant bacteria.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from infections caused by antibiotic-resistant enterococci.
Not a fit: Patients with infections caused by bacteria that are not enterococci may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that are effective against resistant bacterial infections.
How similar studies have performed: Previous research has shown promise in understanding antibiotic resistance mechanisms, but this specific approach to targeting peptidoglycan synthases is relatively novel.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Kristich, Christopher J — Medical College of Wisconsin
- Study coordinator: Kristich, Christopher J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.