Understanding how certain bacteria produce substances that fight infections
Official title: Genetic basis of metabolite production against clinically-derived pathogens
Funded at Bowling Green State University · NIH-10359347 · Data updated 2026-11-12
This study is looking at how certain bacteria can create substances that fight off tough infections caused by drug-resistant germs, with the hope of finding new antibiotics to help people who are dealing with serious bacterial infections.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Bowling Green State University NIH-funded |
| Lab location | 1 site (Bowling Green, United States) |
| Project start | May 1, 2018 |
| Project end | August 31, 2025 |
| Funding year | 2021 |
| Award (this year) | $439,600 |
| NIH project number | 2R15GM124585-02 |
| Project ID | NIH-10359347 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suffering from infections caused by multi-drug resistant bacteria, particularly those with conditions like cystic fibrosis.
✕Less likely to help
Patients with infections caused by non-bacterial pathogens or those who do not have multi-drug resistant infections may not benefit from this research.
What this research studies
This research investigates the genetic mechanisms behind how specific bacteria can produce metabolites that combat multi-drug resistant (MDR) pathogens. By analyzing environmental strains of Pseudomonas, the study aims to identify novel antibiotics that can effectively treat infections caused by resistant bacteria. The approach involves genetic analysis and testing of these metabolites against various pathogens, which could lead to new treatment options for patients suffering from severe bacterial infections.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that effectively treat infections caused by multi-drug resistant bacteria.
How similar studies have gone: Other research has shown promise in discovering new antibiotics from environmental bacteria, indicating that this approach could yield significant results.
Where this research is happening
-
Bowling Green State University
Bowling Green, United States Active
Researchers
- Principal investigator: Wildschutte, Hans — Bowling Green State University
- Study coordinator: Wildschutte, Hans
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.