Understanding how certain bacteria invade human cells
Functional and Structural Analysis of the Dot/Icm Type IVB Secretion Machine
This study is looking at how certain bacteria, like Legionella and Coxiella, use a special system to invade our cells, and by understanding how this system works, we hope to find new ways to treat infections caused by these germs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10891500 on NIH RePORTER |
What this research studies
This research investigates the Dot/Icm type IV secretion system used by the bacteria Legionella pneumophila and Coxiella burnetii to invade human cells. By employing advanced imaging techniques like cryo-electron tomography, the study aims to uncover the structure and function of this secretion machine, which is crucial for the bacteria's ability to replicate inside host cells. The research will also explore how specific proteins are involved in the assembly and operation of this system, potentially revealing new targets for therapeutic intervention. Patients may benefit from insights gained about bacterial infections and their treatment.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with infections caused by Legionella pneumophila or Coxiella burnetii.
Not a fit: Patients with infections caused by other types of bacteria not related to Legionella or Coxiella may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating infections caused by these bacteria.
How similar studies have performed: Other research has shown success in understanding bacterial secretion systems, making this approach promising and not entirely novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Liu, Jun — Yale University
- Study coordinator: Liu, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.