Understanding how certain bacteria interact in dental plaque formation
Regulation in Fusobacterium-mediated coaggregation
This study is looking at how a specific bacteria called Fusobacterium nucleatum interacts with other bacteria in dental plaque, which is important for understanding gum disease, and it aims to find out what genes help these bacteria stick together, so we can learn more about how they affect our oral and overall health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10847503 on NIH RePORTER |
What this research studies
This research investigates the interactions between different bacteria in dental plaque, focusing on Fusobacterium nucleatum, which plays a crucial role in the development of periodontal diseases. By utilizing a newly developed gene deletion system, the study aims to identify the genetic factors that regulate how Fusobacterium aggregates with other bacteria. This could lead to a better understanding of the microbial community in the mouth and its implications for oral and systemic health. The research employs advanced genetic techniques to manipulate bacterial genes and observe the effects on coaggregation.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing periodontal disease or are at risk for oral health issues.
Not a fit: Patients with no dental issues or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for periodontal diseases and potentially reduce the risk of associated systemic conditions.
How similar studies have performed: Previous research has shown success in understanding bacterial interactions in dental plaque, but this specific approach using genetic manipulation is relatively novel.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Wu, Chenggang — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Wu, Chenggang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.