Understanding how certain bacteria inject proteins into host cells
Structure and Function of the Salmonella type III secretion sorting platform
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11101642
This study is looking at how harmful bacteria send proteins into our cells, which helps them cause infections, and by understanding this process better, we hope to find new ways to fight these infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11101642 on ClinicalTrials.gov |
What this research studies
This research investigates the structure and function of a specialized system used by pathogenic bacteria to inject proteins into human cells. By using advanced techniques like super-resolution microscopy and cryo-electron microscopy, the team aims to uncover how these bacteria select and transport their effector proteins. This knowledge could lead to new strategies for combating bacterial infections by targeting the mechanisms these pathogens use to manipulate host cells.
Who could benefit from this research
Good fit: Patients with infections caused by gram-negative bacteria, such as those caused by Salmonella or Bordetella pertussis, would be ideal candidates to benefit from this research.
Not a fit: Patients with infections caused by non-gram-negative bacteria or those unrelated to the mechanisms studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments or preventive measures against infections caused by pathogenic bacteria.
How similar studies have performed: Other research has shown success in understanding bacterial secretion systems, making this approach both relevant and promising.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LARA-TEJERO, MARIA — YALE UNIVERSITY
- Study coordinator: LARA-TEJERO, MARIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.